Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung

► Oxidative stress and tissue hypoxia underlie the pathogenesis of radiation injury in lung tissue. ► Hypoxia-associated gene expression is dynamically altered in lung tissue after radiation. ► mRNA expression and protein stabilization of HIF-1α and HIF-2α differ with respect to time. ► AEOL10150 reduces expression of 31 hypoxia-associated genes elevated in response to radiation.