| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738114 | Free Radical Biology and Medicine | 2012 | 16 Pages |
Abstract
⺠We observed that IL-6 is an endogenous neuroprotectant in response to trimethyltin (TMT) toxicity. ⺠IL-6 KO mice are more susceptible to TMT seizures than either TNF-α or IFN-γ KO mice. ⺠Recombinant IL-6 attenuates oxidative burden and neurodegeneration in TMT-treated IL-6 KO mice. ⺠We suggest that IL-6 activates Nrf2/PI3K-dependent signaling for neuroprotection.
Keywords
PI3Kγ-GCLHeme oxygenase-1TMTIFN-γGSSGHO-1GSHNrf2IL-6ROSinterferon-γinterleukin-6TrimethyltinOxidative stresstumor necrosis factor-αFree radicalsNF-E2-related factor 2nuclear factor E2-related factor 2TNF-αPhosphoinositol 3-kinaseγ-glutamylcysteine ligasewild typeHippocampusreduced glutathioneGlutathioneoxidized glutathioneReactive oxygen species
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Authors
Hoang-Yen Phi Tran, Eun-Joo Shin, Kuniaki Saito, Xuan-Khanh Thi Nguyen, Yoon Hee Chung, Ji Hoon Jeong, Jae-Hyung Bach, Dae Hun Park, Kiyofumi Yamada, Toshitaka Nabeshima, Yukio Yoneda, Hyoung-Chun Kim,