CFTR is the primary known apical glutathione transporter involved in cigarette smoke-induced adaptive responses in the lung

► Cigarette smoke (CS) exposure induces an increase in lung epithelial lining fluid (ELF) GSH levels. ► CFTR mediates 50% of the ELF GSH under both basal and CS exposure. ► Loss of GSH-transporting proteins BCRP and MRP2 had no effect on ELF GSH levels.