Mitochondrial permeability transition pore opening induces the initial process of renal calcium crystallization

Article ID	Journal	Published Year	Pages	File Type
10738118	Free Radical Biology and Medicine	2012	11 Pages	PDF

Abstract

âº The physiological role of mitochondrial permeability transition pore (mPTP) opening in renal calcium crystallization was examined. âº Cyclosporine A decreases oxidative stress by blocking mPTP opening in the kidney. âº Decreasing renal oxidative stress prevents renal calcium crystallization. âº Blocking mPTP opening prevents renal calcium crystallization.

Keywords

MDA TMRE 4-HNE OPN COM MPTP 8-OHdG 4-hydroxy-2-nonenal 8-hydroxy-2′-deoxyguanosine ROS tetramethylrhodamine ethyl ester Ethylene glycol Osteopontin mitochondrial permeability transition pore CSA Tem Oxidative stress Free radicals SOD Superoxide dismutase Cyclosporine A malondialdehyde Transmission electron microscopy calcium oxalate monohydrate Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

Preview

Mitochondrial permeability transition pore opening induces the initial process of renal calcium crystallization

Authors

Kazuhiro Niimi, Takahiro Yasui, Masahito Hirose, Shuzo Hamamoto, Yasunori Itoh, Atsushi Okada, Yasue Kubota, Yoshiyuki Kojima, Keiichi Tozawa, Shoichi Sasaki, Yutaro Hayashi, Kenjiro Kohri,