Article ID Journal Published Year Pages File Type
10738125 Free Radical Biology and Medicine 2012 13 Pages PDF
Abstract
► Adenosine monophosphate-activated protein kinase (AMPK) is activated by oxidants. ► AMPK suppresses NAD(P)H oxidase. ► Dysfunctional AMPK results in oxidative stress.
Keywords
pKaCaMKKβTGFβ1TAK1TACHUVECRNSAAAeNOSTZDET-1VSMCPDGFBH4PKCANGIIPGC-1αPDINF-κBEGFAICARAMPKTNFαSarcoplasmic/endoplasmic reticulum Ca2+ ATPase7-KCSMCLKB15,6,7,8-tetrahydrobiopterin7-KetocholesterolNAD(P)HNAD(P)H oxidaseNOxO2•−ONOO−ROSAbdominal aortic aneurysmAngiotensin IIsuperoxide anionApoeapolipoprotein Eendothelin 1cardiovascular diseaseCardiovascular diseasesTransforming growth factor β1transforming growth factor-β-activated kinase 1transverse aortic constrictiontumor necrosis factor αThiazolidinedioneFree radicalsCVDSODHuman umbilical vein endothelial cellSmooth muscle cellVascular smooth muscle cellEndothelial cellVascular smooth muscle cellsEndothelial cellsBlood cellsendothelial nitric oxide synthaseSuperoxide dismutaseendoplasmic reticulumepidermal growth factorPlasma membraneplatelet-derived growth factornuclear factor κBSERCAwild typenicotinamide adenine dinucleotide phosphate reduced formprotein disulfide isomeraseprotein kinase AProtein kinase Cadenosine monophosphate-activated protein kinasePeroxynitritePreconditioningliver kinase B1reactive nitrogen speciesReactive oxygen speciesthromboxane A2 receptor
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Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
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