| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738135 | Free Radical Biology and Medicine | 2012 | 12 Pages |
Abstract
⺠We investigated the role of HIF1α in hypoxia-induced injury in steatotic hepatocytes. ⺠Under hypoxia, steatosis led to greater intracellular and nuclear oxidative stress. ⺠This led to cellular damage due to HIF1α inactivation. ⺠HIF1α inactivation was due to inhibition of the NF-κB pathway. ⺠Thus, HIF1α inactivation facilitates hypoxic injury in fat-loaded hepatocytes.
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Authors
Sarit Anavi, Noga Budick Harmelin, Zecharia Madar, Oren Tirosh,