| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738137 | Free Radical Biology and Medicine | 2012 | 8 Pages |
Abstract
⺠Interleukin-13 (IL-13) is expressed in airway and lung vascular smooth muscle cells (SMCs). ⺠PDGF promotes IL-13 gene transcription via NAD(P)H oxidase-generated H2O2. ⺠This oxidant signaling mechanism may involve iron-dependent protein carbonylation. ⺠This oxidant signaling mechanism occurs upstream of STAT3. ⺠IL-13 is involved in PDGF-induced growth of airway SMCs, but not lung vascular SMCs.
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Authors
Geetanjali Bansal, Chi-Ming Wong, Lingling Liu, Yuichiro J. Suzuki,