| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738139 | Free Radical Biology and Medicine | 2012 | 8 Pages |
Abstract
⺠Glutathione peroxidase 1/2 double-KO mice are strain-dependently prone to ileocolitis. ⺠129 strain mice have higher lactoperoxidase (Lpo) gene expression than B6 in colon epithelium. ⺠Lpo DNA is more methylated in 129 than B6, DKO than WT, and mature than young mice. ⺠Lpo DNA methylation does not result from inflammation nor lead to gene expression. ⺠Only the full-length variant of colon Lpo mRNA produces an active enzyme.
Keywords
qPCR129TPODKODUOXLPORT-PCREPOCOBRAGPXORFBmi1C57BL/6JMPONOxeosinophil peroxidaseNADPH oxidaseThyroid peroxidasedual oxidaseFree radicalsDextran sulfate sodiumopen reading frameLactoperoxidaseDNA methylationmyeloperoxidasedouble knockoutquantitative real-time polymerase chain reactionglutathione peroxidase
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Authors
Byung-Wook Kim, R. Steven Esworthy, Maria A. Hahn, Gerd P. Pfeifer, Fong-Fong Chu,