Article ID Journal Published Year Pages File Type
10738146 Free Radical Biology and Medicine 2012 14 Pages PDF
Abstract
► Establishes a free radical-based mechanistic model for nonalcoholic steatohepatitis. ► Purinergic receptor 7 (P2X7) triggers NADPH oxidase in Kupffer cells. ► P2X7 receptor-NADPH axis exacerbates NASH of obesity.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice
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