| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738149 | Free Radical Biology and Medicine | 2012 | 8 Pages |
Abstract
⺠We developed an LC-MS/MS method for determinations of 8-oxo-dGsn and 8-oxo-Gsn. ⺠Oxidative DNA and RNA damage increased with aging in SAMR1 and SAMP8 mice. ⺠There were tissue-specific patterns in the basal level of DNA and RNA oxidation. ⺠The ratios of 8-oxo-Gsn to 8-oxo-dGsn in urine were much higher than in tissues.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Wei Gan, Ben Nie, Fei Shi, Xin-Min Xu, Jian-Chang Qian, Yasumitsu Takagi, Hiroshi Hayakawa, Mutsuo Sekiguchi, Jian-Ping Cai,