PPARÎ´ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-ÎºB and inhibition of the PKCÎ±/MEK1/2/ERK1/2/AP-1 pathway

Article ID	Journal	Published Year	Pages	File Type
10738152	Free Radical Biology and Medicine	2012	10 Pages	PDF

Abstract

âº Peroxisomal proliferator-activated receptor Î´ (PPARÎ´) activation prevents radiation-induced oxidative stress/inflammation. âº PPARÎ´ inhibits NF-ÎºB via transrepression by physically interacting with its p65 subunit. âº PPARÎ´ prevents activation of the PKCÎ±/MEK1/2/ERK1/2/AP-1 pathway. âº PPARÎ´ activation modulates radiation-induced microglial proinflammatory response.

Keywords

MCP-1 extracellular signal-related kinase 1/2 mitogen-activated protein kinase kinase 1/2 Radiation-induced brain injury PPARδ PKCα WBI AP-1 IL-1β ICAM-1 COX-2 NF-κB ERK1/2 MEK1/2 ROS inflammation Interleukin-1β whole-brain irradiation ionizing radiation tumor necrosis factor-α CNS Free radicals central nervous system Cyclooxygenase-2 TNF-α nuclear factor κB Microglia monocyte chemoattractant protein-1 activator protein-1 Protein kinase Cα Reactive oxygen species