| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738153 | Free Radical Biology and Medicine | 2012 | 6 Pages |
Abstract
⺠Reactive oxygen species are important precursors for DNA glycation in vitro. ⺠Primary embryonic fibroblasts were obtained from mutant mice deficient in MnSOD. ⺠Mitochondrial DNA glycation is increased in Sod2â/+ compared to Sod2+/+ fibroblasts. ⺠Nuclear DNA glycation is not affected by MnSOD deficiency. ⺠MnSOD deficiency does not influence glycation or oxidation of cytosolic proteins.
Keywords
RCSSDSCelCEdGMnSODPSANε-(carboxyethyl)lysineCMLnDNASDHMEFDNPHXanthine oxidase2,4-dinitrophenylhydrazineMitochondrial DNANuclear DNANε-(carboxymethyl)lysineROSOxidative stressmtDNAFree radicalssodium dodecyl sulfateAgeMn superoxide dismutasemanganese superoxide dismutasesuccinate dehydrogenaseAdvanced glycation end-productadvanced glycation end-productsmouse embryonic fibroblastMitochondriapassagereactive carbonyl speciesReactive oxygen species
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Authors
Viola Breyer, Ingrid Weigel, Ting-Ting Huang, Monika Pischetsrieder,