| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738157 | Free Radical Biology and Medicine | 2012 | 13 Pages |
Abstract
⺠A NRF2-knockdown stable ovarian carcinoma cell line, SKOV3, was established. ⺠NRF2 knockdown resulted in G0/G1 cell cycle arrest and tumor growth retardation in mouse xenografts. ⺠ErbB2 expression was decreased in SKOV3 and breast cancer BT-474 cells by NRF2 knockdown. ⺠Reduced ErbB2 expression in these cells was associated with docetaxel sensitization.
Keywords
UGT1A6GADD45AGCLCNQO1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2AKR1C1NACGSHNrf2ERBB2Interfering RNA3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideMTTN-acetylcysteineNAD(P)H:quinone oxidoreductase 1ROSDocetaxelFree radicalsOvarian cancerBreast cancerantioxidant-response elementNF-E2-related factor-2AREPropidium iodideGlutathioneglutathione reductaseReactive oxygen species
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Authors
Sarala Manandhar, Bo-hyun Choi, Kyeong-Ah Jung, In-geun Ryoo, Mingu Song, Su Jin Kang, Han-Gon Choi, Jung-Ae Kim, Pil-Hoon Park, Mi-Kyoung Kwak,