| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738162 | Free Radical Biology and Medicine | 2012 | 7 Pages |
Abstract
⺠Mn porphyrin-based SOD mimic, MnTnHex-2-PyP5+, was optimized to reduce its toxicity. ⺠Introduction of oxygen atoms into all 4 hexyl chains gave rise to the superb SOD mimic MnTnBuOE-2-PyP5+. ⺠Positioning of oxygen atoms deep within hexyl chains preserved the lipophilic character of MnTnHex-2-PyP5+. ⺠MnTnBuOE-2-PyP5+ is twice more potent SOD mimic, but few-fold less toxic, than MnTnHex-2-PyP5+.
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Authors
Zrinka Rajic, Artak Tovmasyan, Ivan Spasojevic, Huaxin Sheng, Miaomiao Lu, Alice M. Li, Edith B. Gralla, David S. Warner, Ludmil Benov, Ines Batinic-Haberle,