| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738165 | Free Radical Biology and Medicine | 2012 | 11 Pages |
Abstract
⺠Intracellular glutathione (GSH) depletion is the prime hallmark of the progression of apoptosis. ⺠Curcumin suppresses human leukemic cell growth via reactive oxygen species-independent GSH depletion. ⺠Curcumin downregulates inhibitor of apoptosis proteins in human leukemic cells. ⺠Curcumin inhibits sphingomyelin synthase activity in human leukemic cells. ⺠GSH regulates caspase-dependent Cer generation and apoptosis induced by curcumin.
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Authors
Jaleel Kizhakkayil, Faisal Thayyullathil, Shahanas Chathoth, Abdulkader Hago, Mahendra Patel, Sehamuddin Galadari,