| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738168 | Free Radical Biology and Medicine | 2012 | 9 Pages |
Abstract
⺠A direct-current electrical field (DCEF) induces directional migration and reactive oxygen species generation in fibrosarcoma cells. ⺠Superoxide, but not hydrogen peroxide, mediates the fibrosarcoma electrotaxis. ⺠Superoxide is essential for DCEF-induced cytoskeleton reorganization. ⺠Superoxide plays critical roles in DCEF-induced ERK activation. ⺠Superoxide-mediated electrotaxis depends on the activation of ERKs.
Keywords
DPIPI3KElectrotaxisTEPMnSODmCATDCFH-DANADPHMAPKROSHydrogen peroxidedichlorofluorescein diacetatediphenylene iodoniumFree radicalsSuperoxidemanganese superoxide dismutaseMitochondrial superoxide dismutasePhosphatidylinositol 3-kinasenicotinamide adenine dinucleotide phosphateHydroethidinemitogen-activated protein kinaseCatalaseReactive oxygen species
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Authors
Fei Li, Hui Wang, Li Li, Chuanshu Huang, Jiangkai Lin, Gang Zhu, Zhi Chen, Nan Wu, Hua Feng,