| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738169 | Free Radical Biology and Medicine | 2012 | 6 Pages |
Abstract
⺠VAS2870 suppresses production of ROS in skeletal muscle sarcoplasmic reticulum. ⺠O2-coupled redox regulation of RyR1 by Nox4 is thereby abrogated. ⺠VAS2870 directly modifies Cys thiols within RyR1. ⺠Mass spectrometric analysis demonstrates thiol alkylation by VAS2870. ⺠Off-target effects of VAS2870 may replicate redox effects of ROS.
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![Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)](/preview/png/10738169.png "First Page Preview: Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)")
Authors
Qi-An Sun, Douglas T. Hess, Benlian Wang, Masaru Miyagi, Jonathan S. Stamler,