| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738172 | Free Radical Biology and Medicine | 2012 | 11 Pages |
Abstract
⺠Oxidative stress and inflammation are elevated in renal tissues after rhabdomyolysis. ⺠Antioxidants bisphenol/ascorbate synergize to inhibit renal oxidation/inflammation. ⺠Not all markers of acute kidney injury improved indicating that renal dysfunction persists. ⺠Lipid- and water-soluble antioxidants differ in their effect on rhabdomyolysis.
Keywords
CCL2/MCP-1HPSSα-TOHHemeoxygenase-1F2-isoprostanesGFReNOSPTPRT-PCRcGMPPBSAKICCRHO-18-iso-prostaglandin F2αNFκBβ-actinacute kidney injuryAntioxidantbeta-actinOxidative stresstumor necrosis factor alphaRhabdomyolysisendothelial nitric oxide synthaseBurnsTNF-αnuclear factor kappa-BPhosphate-buffered salineMyoglobinMyoglobinuriaAcute renal failurereverse transcription polymerase chain reactionVit Cvitamin CProtein tyrosine phosphataseunesterified cholesterolCreatinine clearance
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Authors
Ludwig K. Groebler, Xiao Suo Wang, Hyun Bo Kim, Anu Shanu, Farjaneh Hossain, Aisling C. McMahon, Paul K. Witting,