| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738173 | Free Radical Biology and Medicine | 2012 | 8 Pages |
Abstract
⺠Urate repairs Trp and Tyr radicals efficiently in proteins. ⺠The rate constants and the efficiency of the repair depend on the protein. ⺠Urate inhibits electron transfer from Tyr to Trp radicals in chymotrypsin but not in pepsin. ⺠Urate may be an important repair agent/antioxidant in vivo. ⺠Loss of ascorbate is expected to be the net result of the repair.
Keywords
ChySDSCTABPEPLACα-ChymotrypsinGSHHSAhuman serum albuminAntioxidantcetyltrimethylammonium bromideUric acidUrateProtein oxidationTryptophanTryptophan radicalProtein repairTyrosinePulse radiolysisFree radicalsAscorbyl radicalTyrosine radicalProtein radicalsodium dodecyl sulfateLactoglobulinlysozymeRate constantPepsinGlutathione
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Authors
Anastasia S. Domazou, Hongping Zhu, Willem H. Koppenol,