| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738178 | Free Radical Biology and Medicine | 2012 | 9 Pages |
Abstract
⺠Inhaled nanoparticles (nPM) induce phase II enzymes systemically in young mice. ⺠Middle-aged mice had elevated phase II enzymes, but induction by nPM was impaired. ⺠Nrf2 increased with age and was induced by nPM in young but not middle-aged mice. ⺠Nrf2 inhibitors, c-Myc and Bach1, increased with age along with depressed induction. ⺠Depressed enzyme induction by nPM in aging may increase air pollution vulnerability.
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Authors
Hongqiao Zhang, Honglei Liu, Kelvin J.A. Davies, Constantinos Sioutas, Caleb E. Finch, Todd E. Morgan, Henry Jay Forman,