Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse

Article ID	Journal	Published Year	Pages	File Type
10738184	Free Radical Biology and Medicine	2012	16 Pages	PDF

Abstract

âº Parkinson disease involves dopamine- and mitochondria-mediated oxidative stress. âº Oxidative stress induced by environmental toxins is linked to sporadic parkinsonism. âº Amphetamine neurotoxicity has similarities with Parkinson disease pathophysiology.

Keywords

SNCA DAT α-Syn LRRK2 MPTP NMDA PINK1 1-methyl-4-phenylpyridinium MAO N-methyl-d-aspartate ASK1 VMAT2 LRR UCHL1 Lamp-2a Short-interfering RNA Non-amyloid-β component lysosome-associated membrane protein 2a 6-OHDA 6-Hydroxydopamine CMA ROC NAC Chaperone-mediated autophagy Mitochondrial DNA iPS l-DOPA MPP+PTEN-induced putative kinase 1 ROS siRNA Trx1 α-synuclein Amphetamines Mitochondrial dysfunction Dopamine transporter Lewy body Parkinson disease Oxidative stress substantia nigra pars compacta leucine-rich repeat kinase 2 tyrosine hydroxylase Thioredoxin 1 leucine-rich repeat domain Dopamine mtDNA Free radicals electron transport chain induced pluripotent stem Ubiquitin proteasome system monoamine oxidase vesicular monoamine transporter 2 map wild type ETc mitogen-activated protein Reactive oxygen species UPS Ubiquitin