| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738188 | Free Radical Biology and Medicine | 2012 | 9 Pages |
Abstract
⺠Cigarette smoke (CS) stimulates poly(ADP-ribose) (PAR) cycles in A549 cells. ⺠PARP-1 is the key PARP enzyme activated by CS. ⺠Superoxide and hydrogen peroxide are responsible for CS-induced PAR synthesis. ⺠Poly(ADP-ribose) glycohydrolase (PARG) rapidly degrades PAR after CS extract exposure. ⺠Both PARP-1 and PARG promote DNA repair and survival after CS exposure.
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Authors
Katalin Kovács, Katalin Erdélyi, Csaba Hegedűs, Petra Lakatos, Zsolt Regdon, Péter Bai, György Haskó, Ãva Szabó, László Virág,