| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738189 | Free Radical Biology and Medicine | 2012 | 8 Pages |
Abstract
⺠We determined the impact of SOD1 or GPX1 absence on mouse glucose and lipid metabolism. ⺠Absence of SOD1 enhanced glycolysis, but decreased gluconeogenesis in liver. ⺠Absence of SOD1 upregulated the hepatic lipid profile and lipogenesis signaling. ⺠Absence of SOD1 altered the function of five hepatic protein kinases/phosphatases. ⺠Absence of GPX1 exerted little effect on liver glucose and lipid status or regulation.
Keywords
AMPKPPasePTP1BJnk2SREBPGPx1PP2NEFAPTTc-Jun NH2-terminal kinasePEPCKSOD1total triglyceridesAMP-activated protein kinaseCu,Zn-superoxide dismutaseMAPKROSpyruvate tolerance testAntioxidant enzymenonesterified fatty acidFree radicalsMetabolic syndromephosphoenolpyruvate carboxykinaseLipidMouseProtein tyrosine phosphatase 1BProtein phosphataseprotein phosphatase 2mitogen-activated protein kinasetotal cholesterolGlucoseGlucokinaseReactive oxygen species
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Authors
Li Wang, Zongyong Jiang, Xin Gen Lei,