| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738191 | Free Radical Biology and Medicine | 2012 | 10 Pages |
Abstract
⺠HNE causes overexpression of CD36 and β1-integrin receptors on neuronal cells. ⺠Increased expression of these receptors enhanced intracellular accumulation of Aβ. ⺠Blocking these receptors prevented neuronal necrotic cell death by HNE plus Aβ.
Keywords
TUBB3SCA1HNEPSA-NCAMNeuNMDR1DAPITGFβ1MCP-1stem cell antigen 1DPPCRT-PCRAβ24-OHN-CAMGFAPNSEMDAPolysialylated-neural cell adhesion molecule4-ONE4-hydroxynonenalTNFαCD36 scavenger receptor24-Hydroxycholesterol4,6-diamidino-2-phenylindoleNeuron-specific enolaseROSamyloid-βPolyunsaturated fatty acidsPUFAinterleukinAlzheimer's diseaseTransforming growth factor β1tumor necrosis factor αHhelactate dehydrogenaseLDHmalondialdehydeCell deathneural cell adhesion moleculeneuronal nucleireverse transcriptase–polymerase chain reactionMonocyte chemotactic protein-1Glial fibrillary acidic proteinmultidrug resistance protein 1Reactive oxygen species
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Authors
Gabriella Testa, Paola Gamba, Federica Di Scipio, Andrea Elio Sprio, Paolina Salamone, Simona Gargiulo, Barbara Sottero, Fiorella Biasi, Giovanni Nicolao Berta, Giuseppe Poli, Gabriella Leonarduzzi,