| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738192 | Free Radical Biology and Medicine | 2012 | 11 Pages |
Abstract
⺠NOX1 was significantly up-regulated in the heart of septic animal models. ⺠Nox1 deficiency improved cardiac dysfunction and survival in septic mice. ⺠Nox1 deficiency reduced cardiomyocyte apoptosis in septic mice. ⺠Decreased level of phosphorylated Akt in septic heart was blunted by Nox1 deficiency. ⺠NOX1 enhances endotoxin-induced cardiomyocyte apoptosis by regulating Akt signaling.
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Authors
Kuniharu Matsuno, Kazumi Iwata, Misaki Matsumoto, Masato Katsuyama, Wenhao Cui, Ayumi Murata, Hideo Nakamura, Masakazu Ibi, Kanako Ikami, Jia Zhang, Satoaki Matoba, Denan Jin, Shinji Takai, Hiroaki Matsubara, Naoyuki Matsuda, Chihiro Yabe-Nishimura,