| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738193 | Free Radical Biology and Medicine | 2012 | 9 Pages |
Abstract
⺠In diabetes a compensatory mechanism protects retina from initial oxidative damage. ⺠Sustained hyperglycemia overwhelms the compensatory mechanism and damages mtDNA. ⺠Damaged mtDNA compromises the electron transport system. ⺠This initiates a vicious cycle of reactive oxygen species damaging the mitochondria. ⺠Dysfunctional mitochondria accelerate apoptosis and result in diabetic retinopathy.
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Authors
Julia M. Santos, Shikha Tewari, Renu A. Kowluru,