Iron chelation inhibits the development of pulmonary vascular remodeling

► Iron chelation prevents the development of pulmonary vascular remodeling in rats. ► Iron chelation inhibits the growth of pulmonary artery smooth muscle cells. ► The mediators of pulmonary hypertension promote iron-dependent protein oxidation. ► A regulator of RhoA is one protein that is oxidized. ► Patients with pulmonary arterial hypertension have elevated protein oxidation.