| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738196 | Free Radical Biology and Medicine | 2012 | 10 Pages |
Abstract
⺠Macroautophagy plays an important role in the uptake of lipofuscin into lysosomes. ⺠Lysosomes are not required for the formation of fluorescent lipofuscin. ⺠Lipofuscin accumulates in the cytosolic volume after inhibition of macroautophagy. ⺠Lipofuscin accumulates in the cytosol after inhibition of lysosomal activity. ⺠A correlation between cytosolic lipofuscin and cellular viability was shown.
Keywords
LC3Stress-induced premature senescence (SIPS)NH4ClMacroautophagyMEFsMDCLAMP12′,7′-dichlorodihydrofluorescein diacetateH2DCFDAOxidative stressAgingSipsLysosomeLipofuscinmouse embryonic fibroblastsMonodansylcadaverineParaquatLysosomal-associated membrane protein 1autophagy-related geneAmmonium chloride
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Authors
Annika Höhn, Anna Sittig, Tobias Jung, Stefanie Grimm, Tilman Grune,