| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738198 | Free Radical Biology and Medicine | 2012 | 12 Pages |
Abstract
⺠We studied the effects of 2-chlorohexadecanal (2-ClHDA) on brain endothelial cells. ⺠Brain endothelial cells take up and metabolize 2-ClHDA. ⺠2-ClHDA impairs endothelial barrier integrity. ⺠2-ClHDA induces mitochondrial dysfunction and activates caspase 3. ⺠Phloretin provides protection against 2-ClHDA-induced barrier dysfunction.
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Authors
Andreas Ãllen, Günter Fauler, Eva Bernhart, Christoph Nusshold, Helga Reicher, Hans-Jörg Leis, Ernst Malle, Wolfgang Sattler,