| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738207 | Free Radical Biology and Medicine | 2012 | 9 Pages |
Abstract
⺠Nonesterified fatty acids (NEFA) increase mitochondrial superoxide and NAD(P)H oxidase activity in human Schwann cells. ⺠Acipimox reduces triglycerides/NEFA and alleviates neuropathy in Zucker fatty rats. ⺠Hypertriglyceridemia and NEFA, but not glucose intolerance, cause prediabetic neuropathy. ⺠Lipid-lowering agents and antioxidants may find a use in the management of this condition.
Keywords
HSCinsulin receptor βhuman Schwann cellsAcipimoxSNCVMNCVIRβVLDLNEFAIRS-1HDLhigh-density lipoproteinNAD(P)H oxidaseROSDyslipidemiaNonesterified fatty acidsFree radicalsinsulin receptor substrate 1SuperoxideInsulin signalingvery low density lipoproteinLow-density lipoproteinLDLnitrotyrosineReactive oxygen species
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Authors
Sergey Lupachyk, Pierre Watcho, Nailia Hasanova, Ulrich Julius, Irina G. Obrosova,