Activation of p38 MAPK by oxidative stress underlying epirubicin-induced vascular endothelial cell injury

Article ID	Journal	Published Year	Pages	File Type
10738212	Free Radical Biology and Medicine	2012	9 Pages	PDF

Abstract

âº Endothelial cell dysfunction contributes to epirubicin-induced vascular injury. âº Epirubicin induces mitochondrial dysfunction and caspase-dependent apoptosis. âº Oxidative stress plays an important role in epirubicin-induced cell injury. âº Activation of p38 MAPK by oxidative stress is involved in endothelial cell injury.

Keywords

WST-8 PAECs DPPP Jnk c-Jun-N-terminal kinase GSH NAC ERK Epirubicin BSO l-buthionine-(S,R)-sulfoximine MAPK N-acetylcysteine ROS Vascular injury analysis of variance ANOVA Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling Oxidative stress TUNEL Apoptosis diphenyl-1-pyrenylphosphine Endothelial cell mitogen-activated protein kinase p38 mitogen-activated protein kinase (MAPK)extracellular signal-regulated kinase Glutathione Reactive oxygen species