| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738224 | Free Radical Biology and Medicine | 2012 | 8 Pages |
Abstract
⺠We studied if supranutrition of Se induced gestational diabetes in rat dams. ⺠Gestational diabetes was induced by feeding dams Se-yeast at 3 mg Se/kg. ⺠High maternal Se exposure and high-Se feeding led to insulin-resistant pups. ⺠Tissue expression of six insulin signal proteins was altered by the high-Se diet. ⺠Gpx1 and five other selenoprotein genes were linked to the metabolic disorder.
Keywords
PI3KSEPP1Selenoprotein SPGC-1AKT2GDMFPGIRSHOMA-IRFOXO1GAPDHGPXq-PCRFPIROSinsulin tolerance testhomeostasis model assessment of insulin resistancefasting plasma insulinITTtriglycerideForkhead box O1Gestational diabetes mellitusGestational diabetesFree radicalsbasal dietreal-time quantitative PCRSelenoprotein WSelenoproteinSelenoprotein PDietary seleniumphosphoinositide 3-kinaseFasting plasma glucoseInsulin resistanceSelStotal cholesterolglutathione peroxidaseglyceraldehyde-3-phosphate dehydrogenaseReactive oxygen speciesinsulin receptor
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Authors
Min-Shu Zeng, Xi Li, Yan Liu, Hua Zhao, Ji-Chang Zhou, Ke Li, Jia-Qiang Huang, Lv-Hui Sun, Jia-Yong Tang, Xin-Jie Xia, Kang-Ning Wang, Xin Gen Lei,