| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738227 | Free Radical Biology and Medicine | 2012 | 10 Pages |
Abstract
⺠We report a novel and efficient synthesis of a series of new S-acyl glutathione (acyl-SG) thioesters. ⺠Acyl-SG thioesters act as prodrugs, increasing the intracellular glutathione. ⺠Polyunsaturated acyl-SG thioesters possess inherent antioxidant properties. ⺠Acyl-SG thioesters reduce lipid peroxidation and mitochondrial dysfunction in Aβ-treated cells. ⺠Acyl-SG thioesters protect against Aβ-induced neurodegeneration and glial reaction in rat brain.
Keywords
NBMMUFAAβGSHSFAAPPNGSGFAPnucleus basalis magnocellularisPresenilin-1UFACM-H2DCFDAPS-1DMSOIba-1ROSAntioxidantssaturated fatty acidPolyunsaturated fatty acidsPolyunsaturated fatty acidunsaturated fatty acidmonounsaturated fatty acidPUFAFADAlzheimer diseaseFamilial Alzheimer diseaseOxidative stressBODIPYRoom temperatureDimethyl sulfoxideFree radicalsnormal goat serumCholinergic neuronsGlial fibrillary acidic proteinamyloid precursor proteinamyloid-β peptideChATcholine acetyltransferaseGlutathioneReactive oxygen species
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Authors
Mariagioia Zampagni, Daniel Wright, Roberta Cascella, Giampiero D'Adamio, Fiorella Casamenti, Elisa Evangelisti, Francesca Cardona, Andrea Goti, Benedetta Nacmias, Sandro Sorbi, Gianfranco Liguri, Cristina Cecchi,