Article ID Journal Published Year Pages File Type
10738228 Free Radical Biology and Medicine 2012 10 Pages PDF
Abstract
► Paraoxonase-1 (PON1) stimulates the capacity of HDL to mediate cholesterol efflux. ► PON1 upregulates ABCA1 gene and protein expression on J774 macrophages. ► PON1 stimulates the association of apo-AI with ABCA1 to stimulate cholesterol efflux. ► PON1 acts via an apo-AI-like mechanism to mediate cholesterol efflux.
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