Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP

Article ID	Journal	Published Year	Pages	File Type
10738231	Free Radical Biology and Medicine	2012	10 Pages	PDF

Abstract

âº Human regulator of heat-induced transcription (RhitH) is involved in transcriptional regulation of human Mpv17-like protein (M-LPH). âº FOXD3 and GABP are involved in transcriptional regulation of RhitH. âº M-LPH reduces intracellular H2O2 and loss of mitochondrial membrane potential. âº Our data suggest that M-LPH has a mitigating effect on mitochondrial dysfunction.

Keywords

antimycin A Krüppel-associated box EMSA MPV17 GABP Forkhead box D3 foxd3 SOD2 ROS Mitochondrial dysfunction AMA chromatin immunoprecipitation electrophoretic mobility-shift assay Free radicals manganese superoxide dismutase Transcription factor GA-binding protein CHiP KRAB Reactive oxygen species