| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738258 | Free Radical Biology and Medicine | 2012 | 12 Pages |
Abstract
⺠Interplay of tumor suppressor gene pathways and reactive oxygen species summarized. ⺠Cellular levels of p53 determine its pro-oxidant and/or antioxidant functions. ⺠Reactive oxygen species link FoxO to the RB pathway in haematopoietic system. ⺠FoxO has the ability to regulate and to be regulated by reactive oxygen species. ⺠BRCA1 and BRCA2 are involved in protection against oxidative stress.
Keywords
Sirt1GPXGSHMnSODNrf2P21CATBRCA2BRCAp53JnkJun N-terminal kinasePDGFβCDKMAPKp16ROSSp1Oxidative stressATMFree radicalsretinoblastomamanganese superoxide dismutaseplatelet-derived growth factor-βFoxOSpecificity protein 1mitogen-activated protein kinaseBRCA1Breast cancer susceptibility geneCatalasecyclin-dependent kinaseGlutathioneglutathione peroxidaseGlutaminaseReactive oxygen species
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Authors
Beyza Vurusaner, Giuseppe Poli, Huveyda Basaga,