Inflammation-related gene expression by lipid oxidation-derived products in the progression of atherosclerosis

Article ID	Journal	Published Year	Pages	File Type
10738259	Free Radical Biology and Medicine	2012	16 Pages	PDF

Abstract

âº Association of inflammation and lipid oxidation as a driving force in atherogenesis âº Various LDL lipid oxidation products induce a strong pro-atherogenic response âº Redox-signaling by oxidized lipids up-regulates a variety of inflammatory genes

Keywords

CREB EGFR NF-κB PI3K MMP LPS TGF-β1 COX Jnk RAC SMC Nrf2 bFGF HO-1 ATF FAK ERK NOS HUVEC MCP-1 PPAR IκB AP-1 TLR HNE Heme oxygenase-1 BLT Trx PLA2 ICAM VCAM prostanoids 15d-PGJ2 PDGFR LXR c-Jun-N-terminal kinase oxLDL OxPL SREBP-1 lyso-PC POVPC 7α-OH α-EPOX human umbilical vascular endothelial cell PGE receptor PGPC cholestan-3β,5α,6β-triol Janus kinase 15-deoxy-Δ12,14-Prostaglandin J2 4-hydroxy-2-nonenal 4-Hydroxy-2-hexenal 5α,6α-epoxycholesterol 7-Ketocholesterol Oxidized LDL MAPK PAPc ROS Sp-1 Atherosclerosis Aldehydes STAT cyclooxygenase phospholipase A2 Polyunsaturated fatty acid PUFA inflammation Oxysterols interleukin Transforming growth factor-β1 thromboxane tumor necrosis factor-α thioredoxin Toll-like receptor Hhe Free radicals TIMP Smooth muscle cell Endothelial cell Triol Cell signaling nuclear factor E2-related factor 2 antioxidant-responsive element Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)basic fibroblast growth factor TNF-α nuclear factor-κB Phosphatidylinositol 3-kinase Oxidized phospholipid oxidized phospholipids activating transcription factor Leukotrienes Leukotriene Lysophosphatidylcholine lipoxygenase Oxidized low-density lipoprotein Low-density lipoprotein LDL lipopolysaccharide Signal transducer and activator of transcription Metalloproteinase Tissue inhibitor of metalloproteinase inhibitor of NF-κB intercellular adhesion molecule vascular cell adhesion molecule nitric oxide synthase PAF ARE 7α-hydroxycholesterol RAS-related C3 botulinum toxin substrate Monocyte chemotactic protein-1 activator protein-1 cAMP-response element-binding protein Protein kinase mitogen-activated protein kinase prostaglandin JAK liver X receptor focal adhesion kinase Reactive oxygen species thromboxane receptor platelet-derived growth factor receptor Epidermal growth factor receptor peroxisome proliferator-activated receptor