Oxidative stress and diabetes: What can we learn about insulin resistance from antioxidant mutant mouse models?

Article ID	Journal	Published Year	Pages	File Type
10738262	Free Radical Biology and Medicine	2012	13 Pages	PDF

Abstract

âº Oxidative stress is implicated as a cause of insulin resistance and diabetes. âº Obesity and insulin resistance are associated with elevated oxidative damage. âº Genetic antioxidant mutation has limited effect on insulin resistance in lean mice. âº Antioxidant over-expression protects mice from obesity-induced insulin resistance. âº Antioxidants may be beneficial in prevention of glucose metabolism dysfunction.

Keywords

T2DM PTP 8-OHdG MCP-1 MnSOD SOD1 IRS-1 GLUT4 GPX NADPH SOD2 Trx CAT mCAT MSR 4-hydroxynonenal c-Jun N terminal kinase Jnk PI-3K IL-6 4HNE TNFα SOD3 TBAR MDA Prdx MAPK NFκB ROS Akt/PKB interleukin-6 Diabetes Transgenic Oxidative stress tumor necrosis factor α thioredoxin Glucose transporter Type 2 diabetes mellitus electron transport chain insulin receptor substrate 1 Age extracellular superoxide dismutase manganese superoxide dismutase Nuclear factor κ B phosphatase and tensin homolog Phosphatidylinositol 3-kinase malondialdehyde methionine sulfoxide reductase Obesity Insulin resistance thiobarbituric acid reactive substances nicotinamide adenine dinucleotide phosphate 8-hydroxyguanosine ETc Monocyte chemotactic protein-1 Protein-tyrosine phosphatase protein kinase B Peroxiredoxin Adipose Pten mitogen-activated protein kinases glutathione peroxidase Reactive oxygen species insulin receptor