Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10738265 | Free Radical Biology and Medicine | 2012 | 10 Pages |
Abstract
⺠We studied the effects of epicatechin treatment in DOCA-salt induced hypertension. ⺠This flavanol prevented the development of hypertension induced by DOCA-salt. ⺠It restored the endothelial function by reducing superoxide levels. > It also inhibited NADPH oxidase activity and activated the Nrf2 pathway.
Keywords
RT-PCRDOCAET-1Heme oxygenase-1HMOX1eNOSDAPIepicatechinNQO1NADPHGCLCNG-nitro-l-arginine methyl esterSBPNrf2/AREMDANADPH:quinone oxidoreductase 1DPI8-iso-prostaglandin F2αl-NAMEO2•−ROSγ-glutamylcysteine synthetaseAngiotensin IIsuperoxide anionEndothelial dysfunctionendothelin-1NADPH oxidasedeoxycorticosterone acetateAng IIdihydroethidiumdiphenylene iodoniumFree radicalsendothelial nitric oxide synthaseKeap-1DOCA-salt hypertensionsystolic blood pressuremalondialdehydeNrf2 pathwaynicotinamide adenine dinucleotide phosphateDHEreverse transcriptase–polymerase chain reactionReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Manuel Gómez-Guzmán, Rosario Jiménez, Manuel Sánchez, MarÃa José Zarzuelo, Pilar Galindo, Ana MarÃa Quintela, RocÃo López-Sepúlveda, Miguel Romero, Juan Tamargo, Félix Vargas, Francisco Pérez-VizcaÃno, Juan Duarte,