Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension

Article ID	Journal	Published Year	Pages	File Type
10738265	Free Radical Biology and Medicine	2012	10 Pages	PDF

Abstract

âº We studied the effects of epicatechin treatment in DOCA-salt induced hypertension. âº This flavanol prevented the development of hypertension induced by DOCA-salt. âº It restored the endothelial function by reducing superoxide levels. >Â It also inhibited NADPH oxidase activity and activated the Nrf2 pathway.

Keywords

RT-PCR DOCA ET-1 Heme oxygenase-1 HMOX1 eNOS DAPI epicatechin NQO1 NADPH GCLC NG-nitro-l-arginine methyl ester SBP Nrf2/ARE MDA NADPH:quinone oxidoreductase 1 DPI 8-iso-prostaglandin F2α l-NAME O2•−ROS γ-glutamylcysteine synthetase Angiotensin II superoxide anion Endothelial dysfunction endothelin-1 NADPH oxidase deoxycorticosterone acetate Ang II dihydroethidium diphenylene iodonium Free radicals endothelial nitric oxide synthase Keap-1 DOCA-salt hypertension systolic blood pressure malondialdehyde Nrf2 pathway nicotinamide adenine dinucleotide phosphate DHE reverse transcriptase–polymerase chain reaction Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

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Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension

Authors

Manuel Gómez-Guzmán, Rosario Jiménez, Manuel Sánchez, MarÃa José Zarzuelo, Pilar Galindo, Ana MarÃa Quintela, RocÃo López-Sepúlveda, Miguel Romero, Juan Tamargo, Félix Vargas, Francisco Pérez-VizcaÃno, Juan Duarte,