| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738267 | Free Radical Biology and Medicine | 2012 | 8 Pages |
Abstract
⺠Nitric oxide has been previously reported to oxidize mitochondrial cytochrome c. ⺠We now show that this reaction is oxygen concentration dependent. ⺠Nitrogen dioxide scavengers (urate; ferrocyanide) modulate the oxidation. ⺠We construct a kinetic model consistent with nitrogen dioxide as the oxidizing species. ⺠The model predicts a rate constant for cytochrome c oxidation of 3 Ã 106 M-1 s-1.
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Authors
Rebecca S. Silkstone, Maria G. Mason, Peter Nicholls, Chris E. Cooper,