Article ID Journal Published Year Pages File Type
10738285 Free Radical Biology and Medicine 2012 9 Pages PDF
Abstract
► SOD2 was activated during neointima formation in balloon-injured carotid arteries. ► SOD2 knockdown promoted while SOD2 overexpression suppressed the neointima formation. ► SOD2 inhibited vascular smooth muscle cell (SMC) migration and proliferation. ► SOD2 inhibited SMC migration via scavenging O2.- and suppressing PI3/Akt signaling. ► SOD2 is a negative modulator of vascular lesion formation following injury.
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Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
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