Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10738285 | Free Radical Biology and Medicine | 2012 | 9 Pages |
Abstract
⺠SOD2 was activated during neointima formation in balloon-injured carotid arteries. ⺠SOD2 knockdown promoted while SOD2 overexpression suppressed the neointima formation. ⺠SOD2 inhibited vascular smooth muscle cell (SMC) migration and proliferation. ⺠SOD2 inhibited SMC migration via scavenging O2.- and suppressing PI3/Akt signaling. ⺠SOD2 is a negative modulator of vascular lesion formation following injury.
Keywords
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Authors
Jia-Ning Wang, Ning Shi, Shi-You Chen,