Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes

Article ID	Journal	Published Year	Pages	File Type
10738288	Free Radical Biology and Medicine	2012	10 Pages	PDF

Abstract

âº Statins can induce muscle weakness/myopathy. âº In culture, simvastatin induced dose dependent atrophy of human myotubes. âº Statin exposure decreased mitochondrial respiratory function and increased ROS production. âº Activation of apoptosis also evident. âº Findings suggest mitochondrial dysfunction underlies statin-induced myopathy.

Keywords

PCM RCI CoQ10 HMG-CoA DCF-DA PTP FCCP DMSO Mn-SOD ROS Hydrogen peroxide Permeability transition pore Oxidative stress Mitochondrial respiration TUNEL Apoptosis Dimethyl sulfoxide Sarcoplasmic reticulum Superoxide manganese superoxide dismutase Simvastatin Respiratory control index Human skeletal muscle Low-density lipoprotein LDL terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling Mitochondria carbonylcyanide-p-trifluoromethoxyphenylhydrazone Coenzyme Q10 glutamate/malate Reactive oxygen species