| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738305 | Free Radical Biology and Medicine | 2011 | 7 Pages |
Abstract
⺠How is inflammation linked to oxidative tissue damage? ⺠Oxidized phospholipids (OxPL) induced TLR2-dependent gene expression in macrophages. ⺠OxPL induced inflammation in wild-type, but not in TLR2 KO mice. ⺠TLR2 KO mice were protected against CCl4-induced oxidative tissue damage. ⺠We conclude that TLR2 senses oxidative tissue damage by recognizing OxPL.
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Authors
Alexandra Kadl, Poonam R. Sharma, Wenshu Chen, Rachana Agrawal, Akshaya K. Meher, Swetha Rudraiah, Nathaniel Grubbs, Rahul Sharma, Norbert Leitinger,