| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738310 | Free Radical Biology and Medicine | 2011 | 11 Pages |
Abstract
⺠Oxidation of either the lipid or the protein moiety of LDL increases macrophage viability. ⺠Pro-survival modification involves derivatization of amino groups by lipid oxidation products. ⺠Pro-survival oxidation products are mainly unfragmented hydroperoxides and endoperoxides. ⺠Arachidonic acid-derived adducts contain hydroxylactam rings derived from isolevuglandins. ⺠Fluorescence spectra of adducts are similar to those of oxLDL, lipofuscin, and ceroid.
Keywords
oxLDLLPCHNEPKBMPMBHTTPPESI4-hydroxynonenalLMEFBSXTTPI3Kisolevuglandin4-HydroxyhexenalOxidized LDLMS/MSAtherosclerosisapoapolipoproteinArachidonic acidLinoleic acidunsaturated fatty acidProtein modificationAutoxidationTriphenylphosphineHheFree radicalsfetal bovine serumTandem mass spectrometryphosphatidylcholinephosphatidylethanolaminePhosphatidylinositol 3-kinaseLysophosphatidylcholineLow-density lipoproteinLDLMouse peritoneal macrophageOxidation productbutylated hydroxytolueneprotein kinase Belectrospray ionization
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Authors
Maziar Riazy, Marilee Lougheed, Hans H. Adomat, Emma S. Tomlinson Guns, Guenter K. Eigendorf, Vincent Duronio, Urs P. Steinbrecher,