Lipid peroxidation and neurodegenerative disease

Article ID	Journal	Published Year	Pages	File Type
10738317	Free Radical Biology and Medicine	2011	18 Pages	PDF

Abstract

Lipid peroxidation is a complex process involving the interaction of oxygen-derived free radicals with polyunsaturated fatty acids, resulting in a variety of highly reactive electrophilic aldehydes. Since 1975, lipid peroxidation has been extensively studied in a variety of organisms. As neurodegenerative diseases became better understood, research establishing a link between this form of oxidative damage, neurodegeneration, and disease has provided a wealth of knowledge to the scientific community. With the advent of proteomics in 1995, the identification of biomarkers for neurodegenerative disorders became of paramount importance to better understand disease pathogenesis and develop potential therapeutic strategies. This review focuses on the relationship between lipid peroxidation and neurodegenerative diseases. It also demonstrates how findings in current research support the common themes of altered energy metabolism and mitochondrial dysfunction in neurodegenerative disorders.

Keywords

ERK Aβ GAPDH G3P DHAP HNE NFT NF-M IPL N-methyl-d-aspartic acid TPI MDH NF-L NMDA MPTP APP Hsp GFAP DRP-2 dihydropyrimidinase-related protein 2 ENO1 4-hydroxynonenal lactate dehydrogenase B VDAC1 PRX UCHL1 TCA PGK PCAD CR1 EAD tPA 4-hydroxy-2-nonenal BDNF EF-Tu NAD+ROS α-Enolase Aldolase mild cognitive impairment amyotrophic lateral sclerosis tricarboxylic acid Docosahexanoic acid mitochondrial permeability transition pore Alzheimer disease Preclinical Alzheimer Disease ALS Huntington disease Neurodegenerative disease Parkinson disease Positron emission tomography Neurofibrillary tangle DHA dihydroxyacetone phosphate Free radicals electron transport chain Neurofilament light chain SOD Triose phosphate isomerase Superoxide dismutase elongation Factor Tu Brain-derived neurotrophic factor phosphoglycerate kinase Tissue-type plasminogen activator LAD LDH inferior parietal lobule Cerebrospinal fluid CSF MEK malate dehydrogenase MCI Hippocampus ETc PET Lipid peroxidation Proteomics Glial fibrillary acidic protein Heat shock protein amyloid precursor protein mitogen-activated protein kinase kinase Peroxiredoxin amyloid-β peptide pyruvate kinase Voltage-dependent anion channel 1 Creatine kinase Carbonyl reductase high-performance liquid chromatography HPLC extracellular signal-regulated kinase Glutamine synthetase glyceraldehyde-3-phosphate dehydrogenase glyceraldehyde 3-phosphate Reactive oxygen species