| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738353 | Free Radical Biology and Medicine | 2011 | 10 Pages |
Abstract
⺠Oxidative injury plays an important role in retinal degeneration. ⺠Limiting iron bioavailability may protect the retina by reducing formation of ROS. ⺠Zn/DFO provides functional and structural rescue in the rd10 mouse model of RP. ⺠We suggest that modulation of iron bioavailability underlies rescue effect of Zn/DFO.
Keywords
PFAHO1HprtDesferrioxamineAREDSRCSRetinitis pigmentosaONLRPENDS8-OHdGAMDTBARSPDEGPXPBSCATERGDFO8-hydroxydeoxyguanosineBSAROSbovine serum albuminIronelectroretinogramretinal pigment epitheliumAge-Related Eye Disease StudyOxidative stressretinal degenerationFree radicalsSODnormal donkey serumage-related macular degenerationSuperoxide dismutasePhosphodiesteraseouter nuclear layerPhosphate-buffered salinethiobarbituric acid-reactive substanceswild typeheme oxygenase 1paraformaldehydeCatalaseRoyal College of Surgeonsglutathione peroxidaseReactive oxygen species
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Authors
Alexey Obolensky, Eduard Berenshtein, Michal Lederman, Baruch Bulvik, Ruslana Alper-Pinus, Ruth Yaul, Efrat Deleon, Itay Chowers, Mordechai Chevion, Eyal Banin,