| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738363 | Free Radical Biology and Medicine | 2011 | 9 Pages |
Abstract
⺠DNIC are the most abundant NO-derived species in NO-producing RAW 264.7 macrophages. ⺠The rate of DNIC metabolism is O2 independent, with a biological half-life of 80 min. ⺠DNIC form within seconds and can be detected > 24 hours after the NO source is removed. ⺠DNIC formation is dependent upon the dose and duration of NO exposure. ⺠DNIC concentrations can exceed that of intracellular chelatable iron.
Keywords
iNOSSPER/NORSNO•NO(Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolateS-nitrosothiolsDesferrioxamineS-nitrosothiolDNICDTPADFOCIPDMEMLPSDETA/NODulbecco's modified Eagle MediumNO2−NO3−OxymyoglobinDiethylenetriaminepentaacetic acidFree radicalsinducible nitric oxide synthaselipopolysaccharideNitrateNitriteNitric oxide
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Authors
Jason R. Hickok, Sumit Sahni, Hong Shen, Akanksha Arvind, Chloe Antoniou, Leslie W.M. Fung, Douglas D. Thomas,