| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738366 | Free Radical Biology and Medicine | 2011 | 8 Pages |
Abstract
⺠sod-1 over-expression increases levels of cellular ROS and of molecular damage. ⺠sod-1 over-expression effects on lifespan are dependent on DAF-16 (FoxO) and HSF-1. ⺠Increased lifespan is partially suppressed by inactivation of ER stress mediators. ⺠sod-2 (MnSOD) over-expression effects on lifespan are dependent on DAF-16.
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Authors
Filipe Cabreiro, Daniel Ackerman, Ryan Doonan, Caroline Araiz, Patricia Back, Diana Papp, Bart P. Braeckman, David Gems,