| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738487 | Free Radical Biology and Medicine | 2011 | 9 Pages |
Abstract
⺠We study the effects of Hydrogen Sulfide (H2S) on human breast carcinoma-derived endothelial cells (B-TECs). ⺠H2S donors trigger calcium entry and B-TEC migration. ⺠No pro-migratory effect is detected in normal microvascular ECs. ⺠Migration and calcium signals induced by VEGF in B-TECs are drastically reduced when endogenous H2S release is prevented. ⺠We conclude that H2S could be involved in proangiogenic signaling of tumor derived- but not of normal human ECs.
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Authors
Emanuela Pupo, Alessandra Fiorio Pla, Daniele Avanzato, Francesco Moccia, José-Everardo Avelino Cruz, Franco Tanzi, Annalisa Merlino, Daniele Mancardi, Luca Munaron,