| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738489 | Free Radical Biology and Medicine | 2011 | 15 Pages |
Abstract
⺠Cisplatin is an important chemotherapeutic drug that causes nephrotoxicity/nephropathy ⺠The nephrotoxicity of cisplatin involves oxidative/nitrative stress-PARP pathway ⺠PARP-1 deletion/inhibition prevents cisplatin-induced kindey inflammation and injury ⺠PARP inhibition enhances the antitumor effect of cisplatin in human cancer(s)/cells ⺠PARP is a novel therapeutic target to prevent cisplatin's nephrotoxicity
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Authors
Partha Mukhopadhyay, Béla Horváth, Malek Kechrid, Galin Tanchian, Mohanraj Rajesh, Amarjit S. Naura, A. Hamid Boulares, Pál Pacher,